段亮

教授，博士生导师，主任医师

导师资格：博士研究生

招生专业：临床医学

所在院系：同济大学附属上海市肺科医院

联系方式：duan-liang@163.com

研究方向：

气管组织工程和肺癌发生发展的分子机制

现任职务及专业学术任职：

中华医学会胸心外科分会肺癌学组委员

上海市医师协会胸外科医师分会肺癌气管工作组副组长

上海市抗癌协会食管癌专业委员会常委

中华医学会结核分会外科学组委员

医学健康促进会结核病防治分会临床学组委员

医学健康促进会感染分会外科学组委员

上海市抗癌协会胸外科专业委员会委员

科研业绩：

本课题组主要聚焦于气管组织工程和肺癌的发生发展的相关研究。在气管组织工程研究领域，提出采用激光打孔技术，实现了具有足够力学强度的新生气管，通过胶原修饰气管激光打孔脱细胞基质，不但显著提高了细胞接种率，而且实现了均质厚实的气管软骨再生；提出环状构建理念以构建高仿生气管组织，并成功进行长段缺损修复动物模型效果评估。肺癌研究领域，熟练掌握肺部疾病的各种手术，尤其擅长气管和肺段切除，同时进行肺癌发生发展的相关分子机制研究。

作为课题负责人先后主持国家自然科学基金面上项目2项、上海市科委自然基金3项，上海市卫生局课题1项，以通讯作者或第一作者发表论文20余篇。参与编写胸外科专著3部。获得发明及实用新型专业多项，获得上海医学科技奖三等奖1次。

代表性研究结果:

1. Xiang Li, Qiuyuan Li, Fujun Yang, Erji Gao, Lei Lin, Yaqiang Li, Xiao Song, Liang Duan. Neoadjuvant therapy does not increase postoperative morbidity of sleeve lobectomy in locally advanced non-small cell lung cancer. J Thorac Cardiovasc Surg. 2023, S0022-5223(23):00254-4.

2. Erji Gao, Yao Wang, Pengli Wang, Qianyi Wang, Yuxuan Wei, Daiying Song, Huangfang Xu, Jinghao Ding, Yong Xu, Huitang Xia, Ru Chen, and Liang Duan. C-Shaped Cartilage Development Using Wharton's Jelly-Derived Hydrogels to Assemble a Highly Biomimetic Neotrachea for use in Circumferential Tracheal Reconstruction. Advanced Functional Materials. 2023, 2212830:1-17.

3. Erji Gao, Pengli Wang, Feifan Chen, Yong Xu, Qianyi Wang, Hong Chen, Gening Jiang, Guangdong Zhou, Dan Li, Yi Liu, Liang Duan. Skin-derived epithelial lining facilitates orthotopic tracheal transplantation by protecting the tracheal cartilage and inhibiting granulation hyperplasia. Biomaterials Advances, 2022,139:213037.

4. Pengli Wang, Gaoran Xu, Erji Gao, Yong Xu, Leilei Liang, Gening Jiang, Liang Duan. Identification of Prognostic DNA Methylation Signatures in Lung Adenocarcinoma. Oxidative Medicine and Cellular Longevity, 2022:8802303.

5. Erji Gao, Gao Li, Runfeng Cao, Huitang Xia, Yong Xu, Gening Jiang, Kaiyan Xiao, Jie Chen, Ru Chen, Liang Duan. Bionic tracheal tissue regeneration using a ring-shaped scaffold comprised of decellularized cartilaginous matrix and silk fibroin. Composites Part B: Engineering, 2022, 229: 109470.

6. Jinghan Shi, Fei Li, Fujun Yang, Zhengwei Dong, Yan Jiang, Dania Nachira, Justyna Chalubinska-Fendler, Terence T. Sio, Yo Kawaguchi, Hiromitsu Takizawa, Xiao Song, Yang Hu, Liang Duan. The combination of computed tomography features and circulating tumor cells increases the surgical prediction of visceral pleural invasion in clinical T1N0M0 lung adenocarcinoma. Translational Lung Cancer Research, 2021,10(11): 4266-4280.

7. Yong Yang, Shaojun Zhang, Zhengwei Dong, Yong Xu, Xuefei Hu, Gening Jiang, Lin Fan and Liang Duan. Sublobectomy is a safe alternative for localized cavitary pulmonary tuberculosis. Journal of Cardiothoracic Surgery, 2021,16(1):22.

8. Xu Yong, Guo Yifan, Li Yaqiang, Huo Yingying, She Yunlang, Li Hao, Jia Zihao, Jiang Gening, Zhou GuangDong, You Zhengwei, and Duan Liang. Biomimetic Trachea Regeneration Using a Modular Ring Strategy Based on Poly(Sebacoyl Diglyceride)/Polycaprolactone for Segmental Trachea Defect Repair. Advanced Functional Materials,2020,30(42): 2004276.

9. Xu Yong, She Yunlang, Li Yaqiang, Li Hao, Jia Zihao, Jiang Gening, Liang Leilei, and Duan Liang. Multi-omics analysis at epigenomics and transcriptomics levels reveals prognostic subtypes of lung squamous cell carcinoma. Biomedicine & Pharmacotherapy,2020,125: 109859.

10. Xu Yong, Li Yaqiang, Liu Yanqun, Li Hao, Jia Zihao, Tang Yao, Jiang Gening, Zhang Xue, and Duan Liang. Surface modification of decellularized trachea matrix with collagen and laser micropore technique to promote cartilage regeneration. American Journal of Translational Research,2019,11(9):5390-5403.

11. Li Yaqiang, Xu Yong, Liu Yanqun, Wang Zongxin, Chen Weiming, Duan Liang, and Gu Dongyun. Decellularized cartilage matrix scaffolds with laser-machined micropores for cartilage regeneration and articular cartilage repair. Materials Science & Engineering C-Materials for Biological Applications, 2019,105: 110139.

12.  Hu Xuefei, Duan Liang, Liu Hongcheng, and Zhang Lei. Long noncoding RNA LINC01296 induces non-small cell lung cancer growth and progression through sponging miR-5095. American Journal of Translational Research,2019,11(2):895-903.

13. Song Nan, Duan Liang, Fang Zhiyong, Jiang Gening. Uniportal video-assisted thoracoscopic left S4 anatomical segmentectomy. Thoracic Cancer, 2019, 10: 1248-1251.

14. Zhang Yongjun, Xu Yong, Liu Yanqun, Li Dan, Yin Zongqi, Huo Yingying, Jiang Gening, Yang Yong, Wang Zongxin, Li Yaqiang, Lu Fangjia, Liu Yi, Duan Liang, and Zhou Guangdong. Porous decellularized trachea scaffold prepared by a laser micropore technique. Journal of the Mechanical Behavior of Biomedical Materials,2019,90:96-103.

15. Duan Liang, Jiang Gening, and Yang Yong. One hundred and fifty-six cases of anatomical pulmonary segmentectomy by uniportal video-assisted thoracic surgery: a 2-year learning experience. European Journal of Cardio-Thoracic Surgery,2018,54(4):677-682.